Background Intravenous patient-controlled analgesia (IV-PCA) is now regarded as a standard in postoperative pain management. However, there are fewer prior studies of oxycodone-based IV-PCA administration mode for postoperative pain control and incidence of adverse effects related to IV-PCA. In this retrospective study, we compared the IV-PCA with and without background infusion in patients underwent laparoscopic gynecologic surgery.
Methods We reviewed the data from 443 patients who received IV-PCA following elective laparoscopic gynecologic surgery under general anesthesia between January 2015 and July 2017. Numerical rating on a pain intensity scale, IV-PCA administration dose (mL), and incidence of adverse effects related to IV-PCA during the postoperative 48 hours were analyzed.
Results Numerical rating on a pain intensity scale at 0d the IV-PCA doses administered during 024.0±12.3 versus 34.3±11.5 mL, p<0.001), 24 hr (37.6±25.9 versus 48.9±27.5 mL, p<0.001) and throughout the observation period (44.0±26.2 versus 55.1±27.6 mL, p<0.001) were higher in group BD. The incidences of IV-PCA related adverse effects during 024hout the observation period (14.9% versus 30.8%, p<0.001) were higher in group BD, and IV-PCA withdrawal was also more frequently observed in group BD (12.7% versus 21.7%, p=0.019) at 0eratively.
Conclusion Oxycodone-based IV-PCA with background infusion showed no beneficial effect on the PCA consumption and the incidence of adverse effects under the similar analgesic effect during postoperative pain management following laparoscopic gynecologic surgery.